New Oral Drugs for MS

Pills and Injections

 

A pill.  Wouldn’t that be nice?  We’re not asking for much.  Why do all of those other diseases get pills and we get injections?  I know – Diabetes gets shots too.  And I’m sure there are others.  My apologies to those diseases that suck like MS because you have to  give yourself a shot.

Sure, there have been pills that we take for symptom relief or control.  But the disease-modifiers – the ones that we hope are holding the MonSter at bay – they’ve been rather elusive.  There are 2 oral disease-modifying drugs currently approved for Multiple Sclerosis.  The first, Gilenya or Fingolimod, has been on the U.S. market since 2010, with a prescribing revision coming in April of 2012 due to heart issues.  It  has some good numbers: 54% reduction in relapses and 30% reduction in risk of disability progression.  That sounds pretty good.  Well, there were those deaths. But – apparently the screening was tightened up to exclude those with heart problems and the FDA was good with that.  First dose monitoring in your doctor’s office is required for 6 hours with EKG’s before and after the 6-hour window.  A little worrisome, but compared to shooting up, it’s not sounding too bad.

Then along came Aubagio, FDA approved in September 2012.  It reduces relapses by about 33%. Maybe not as impressive as Gilenya’s 54% reduction, but people weren’t grabbing their chest and falling over either. This one requires a close watch on liver enzymes.  There’s a boxed warning, in fact, about potential liver damage and another one about causing significant birth defects.  And, it stays in your system for 8 months.  Not a good choice if your of child-bearing age.  What was the average age of diagnosis?  Oh yeah – 20-50.  By the way, Aubagio also lists peripheral neuropathy as a potential side effect.  Hmmm – already got that.  Thank you.

So – until now – them’s been our choices.  My doctor has been touting a new drug that’s been in the pipeline for several years.  You may have heard of it.  It’s call BG-12 – dimethyl fumarate.  The New England Journal of Medicine reported in it’s September 20, 2012 issue that BG-12 showed, in Phase 3 trials, a 53% reduction in relapses and a 38% reduction in progression.  In it’s conclusion, the Journal noted BG-12 “significantly reduced the proportion of patients who had a relapse, the annualized relapse rate, the rate of disability progression, and the number of lesions on MRI.”  Sounds pretty good, huh?  Are there side affects you ask?  Well, of course there are.  These include “flushing and gastrointestinal events” (assumedly those would require “flushing” as well).   Originally BG-12 was slated for FDA approval in December, 2012.  For whatever reason – and I’m assured it wasn’t something catastrophic like a missed brain aneurysm side affect – it was pushed back several months.  However, it appears to be on-track for approval in March of 2013.  So – now we’ll have some choices that don’t involve needles.

I recently chose to discontinue my affair with the needle – as documented in my post Needles No More.  I would certainly entertain an oral remedy.  For now, at least, I’m done.  I’m not interested in any more needles.  A pill?  Well, yeah, maybe.  Then there’s LDN.  But that’s another blog post altogether – and a podcast.  So – what are your thoughts on going “on the pill”?  Have you made the jump?  Will you?  Are you okay with the shots?  Maybe you feel like “if it ain’t broke don’t fix it.”  Share with the community. Please, leave a comment in the comment section below this post.  Thanks.

 

It seems to help the stress, just to say F-U-M-S!!

Special thanks to www.FreeDigitalPhotos.net

 

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4 Responses to “New Oral Drugs for MS”

  1. Geoff Says:

    The word in England is that Teva (who make Copaxone) are trying to delay the introduction of BG12. They are reputedly developing an oral DMD with another drug company. Looks like market share is the real reason.
    The English regulatory body called NICE (and called other things) are already considering whether to approve BG12, along with laquinimod and teriflunomide.
    If approved, these will be available via our state health system (the NHS).

    Reply

  2. Julia Forys Gulash Says:

    I’d try it. I see my Dr next week & he’s suppose to let me know about the LDN, because I refused to take anymore injections.(That’s another story)

    Reply

  3. Misty Werth-Kirk Says:

    I have been on Tysabri since 2007 and was excited about the new oral meds that came out and are getting ready to come out. However, with thec severity and how quickly I can go from functioning to a complete vegetative state, my Neurologist doesnt recommend any of the new oral pills or me going thru the 90 day wash out. Im disappointed but aslong as Tysabri keeps me going I dont mind the trip to get my infusion. Maybe in future there will be an oral pill that will be suitable for me too……..

    Reply

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  1. To Take Drugs or Not - That Is The Question - FUMS: Giving Multiple Sclerosis The Finger - June 9, 2015

    […]  Based on what’s found – I’ll be armed to make a good decision.  There are new drugs now – I won’t even have to consider injections again.  Knowledge is power. […]

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